Journal of the American Heart Association · 2025
Anatomical and Functional Predictors of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation.
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Jung Susanne, Kondruweit Markus, Marwan Mohamed, Achenbach Stephan
Аннотация
BACKGROUND: High-degree atrioventricular block with the need for permanent pacemaker (PPM) implantation represents a frequent complication after transcatheter aortic valve implantation (TAVI). Extension of indication for TAVI toward subjects with lower surgical risk requires reduction of the likelihood for the need for PPM implantation. The aim of the current analysis was to identify predictors of the need for PPM implantation after TAVI.
METHODS AND RESULTS: In a cohort of 1500 consecutive patients without a PPM undergoing transfemoral TAVI, clinical and procedural characteristics as well as parameters derived from cardiac computed tomography, such as membranous septal length and calcium volumes of the aortic valve cusps and the left ventricular outflow tract were assessed. Median calcium volume of the aortic valve was 552 mm3 (interquartile range [IQR]: 340-811 mm3) in the group of subjects requiring a PPM, which was higher than in the group of subjects not requiring PPM implantation (455 mm3 [IQR: 245-723 mm3], Padj=0.001). The same was true for calcification of the noncoronary cusp (Padj=0.027), left coronary cusp (Padj=0.033), and right coronary cusp (Padj=0.006). In multivariable analysis, calcium volume of the noncoronary cusp (P=0.039; odds ratio [OR], 1.089 per 100 mm3), preexisting complete right bundle-branch block (P<0.001; OR, 9.402), and implantation of a self-expandable prosthesis (P<0.001; OR, 1.856) were significantly associated with PPM implantation after TAVI.
CONCLUSIONS: The current analysis offers a detailed examination of predictors for the need for PPM implantation after TAVI. Our results may contribute to improved risk stratification on the need for PPM implantation after TAVI.
METHODS AND RESULTS: In a cohort of 1500 consecutive patients without a PPM undergoing transfemoral TAVI, clinical and procedural characteristics as well as parameters derived from cardiac computed tomography, such as membranous septal length and calcium volumes of the aortic valve cusps and the left ventricular outflow tract were assessed. Median calcium volume of the aortic valve was 552 mm3 (interquartile range [IQR]: 340-811 mm3) in the group of subjects requiring a PPM, which was higher than in the group of subjects not requiring PPM implantation (455 mm3 [IQR: 245-723 mm3], Padj=0.001). The same was true for calcification of the noncoronary cusp (Padj=0.027), left coronary cusp (Padj=0.033), and right coronary cusp (Padj=0.006). In multivariable analysis, calcium volume of the noncoronary cusp (P=0.039; odds ratio [OR], 1.089 per 100 mm3), preexisting complete right bundle-branch block (P<0.001; OR, 9.402), and implantation of a self-expandable prosthesis (P<0.001; OR, 1.856) were significantly associated with PPM implantation after TAVI.
CONCLUSIONS: The current analysis offers a detailed examination of predictors for the need for PPM implantation after TAVI. Our results may contribute to improved risk stratification on the need for PPM implantation after TAVI.