Clinical nutrition ESPEN · 2022
High-fat low-carbohydrate enteral feeding enriched with olive oil and acute respiratory failure: A double-blind, randomized, controlled trial.
Рандомизированное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Nourmohammadi Mahdieh, Moradi Moghdam Omid, Niakan Lahiji Mohammad, Vahdat Shariatpanahi Zahra
Аннотация
BACKGROUND AND AIM: The study evaluated the impact of two types of high fat diet on the outcomes of acute pulmonary failure.
METHODS: A total of 93 Ventilated acute pulmonary failure patients with enteral feeding were assigned randomly to the control group with carbohydrate-based formula (protein: 20%, fat: 30%, carbohydrate: 50%) and two study groups with fat-based formula, including group A (protein: 20%, In equal proportions of olive and sunflower oil 45%, charbohydrate:35%) and group B (protein: 20%, sunflower oil:45%, charbohydrate:35%). The diets were prescribed for 14 days.
RESULTS: In each group, 16 patients completed the study. The PaCO2 decreased significantly in the study group A compared with the control group at weaning. The risk of separation from mechanical ventilation during study period was eight times higher in the study group A than the control group. On day 10 of intervention, serum hs-CRP decreased significantly in the control group and the study group A compared to the baseline. Serum concentration of total antioxidant capacity was increased significantly in the study group A on day 10 of the intervention, but in the other two groups it was reduced. Gastrointestinal complications, including diarrhea and high gastric residual volume, were not different between the groups.
CONCLUSION: With a fat-based diet high in olive oil, more patients were weaned during the study period. This diet reduced the PaCo2 at weaning, reduced the serum level of hs-CRP, and increased the serum level of total antioxidant capacity concentration. Fat-based diet high in sunflower oil did not have any beneficial effects on outcomes.
METHODS: A total of 93 Ventilated acute pulmonary failure patients with enteral feeding were assigned randomly to the control group with carbohydrate-based formula (protein: 20%, fat: 30%, carbohydrate: 50%) and two study groups with fat-based formula, including group A (protein: 20%, In equal proportions of olive and sunflower oil 45%, charbohydrate:35%) and group B (protein: 20%, sunflower oil:45%, charbohydrate:35%). The diets were prescribed for 14 days.
RESULTS: In each group, 16 patients completed the study. The PaCO2 decreased significantly in the study group A compared with the control group at weaning. The risk of separation from mechanical ventilation during study period was eight times higher in the study group A than the control group. On day 10 of intervention, serum hs-CRP decreased significantly in the control group and the study group A compared to the baseline. Serum concentration of total antioxidant capacity was increased significantly in the study group A on day 10 of the intervention, but in the other two groups it was reduced. Gastrointestinal complications, including diarrhea and high gastric residual volume, were not different between the groups.
CONCLUSION: With a fat-based diet high in olive oil, more patients were weaned during the study period. This diet reduced the PaCo2 at weaning, reduced the serum level of hs-CRP, and increased the serum level of total antioxidant capacity concentration. Fat-based diet high in sunflower oil did not have any beneficial effects on outcomes.