Gas distribution by EIT during PEEP inflation: PEEP response and optimal PEEP with lowest trans-pulmonary driving pressure can be determined without esophageal pressure during a rapid PEEP trial in patients with acute respiratory failure.

Objective. Protective ventilation should be based onlungmechanics and transpulmonary driving pressure (ΔPTP), as this 'hits' the lung directly.Approach. The change in end-expiratory lung volume (ΔEELV) is determined by the size of the PEEP step and the elastic properties of the lung (EL), ΔEELV/ΔPEEP. Consequently, EL can be determined as ΔPEEP/ΔEELV. By calibration of tidal inspiratory impedance change with ventilator inspiratory tidal volume, end-expiratory lung impedance changes were converted to volume changes and lung P/V curves were obtained during a PEEP trial in ten patients with acute respiratory failure. The PEEP level where ΔPTP was lowest (optimal PEEP) was determined as the steepest point of the lung P/V curve.Main results. Over-all EL ranged between 7.0-23.2 cmH2O/L. Optimal PEEP was 12.9 cmH2O (10-16) with ΔPTP of 4.1 cmH2O (2.8-7.6). Patients with highest EL were PEEP non-responders, where EL increased in non-dependent and dependent lung at high PEEP, indicating over-distension in all lung. Patients with lower EL were PEEP responders with decreasing EL in dependent lung when increasing PEEP.Significance. PEEP non-responders could be identified by regional lung P/V curves derived from ventilator calibrated EIT. Optimal PEEP could be determined from the equation for the lung P/V curve.