Oral and oropharyngeal diffuse large B-cell lymphoma and high-grade B-cell lymphoma: A clinicopathologic and prognostic study of 69 cases.
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Rodrigues-Fernandes Carla Isabelly, Junior Arnaldo Gonçalves, Soares Ciro Dantas, Morais Thayná Melo de Lima, do Amaral-Silva Gleyson Kleber, de Carvalho Maria Goretti Freire, de Souza Lucas Lacerda, Pires Fábio Ramôa, Dos Santos Teresa Cristina Ribeiro Bartholomeu, Pereira Débora Lima, Rivero Luis Fernando, Bezerra Kelly Tambasco, de Andrade Bruno Augusto Benevenuto, Romañach Mário José, Agostini Michele, Henao Javier Rendón, Gabriel Amanda de Farias, Dos Santos Pinto Júnior Décio, Martins Manoela Domingues, Pereira Mateus José de Carvalho, Mesquita Ricardo Alves, Gomez Ricardo Santiago, Souto Giovanna Ribeiro, Santos-Silva Alan Roger, Vargas Pablo Agustin, Lopes Márcio Ajudarte, de Almeida Oslei Paes, Pontes Flávia Sirotheau Corrêa, Pontes Hélder Antônio Rebelo, Burbano Rommel Mario Rodríguez, Fonseca Felipe Paiva
Аннотация
STUDY DESIGN: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements.
RESULTS: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively).
CONCLUSION: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases.