Revista da Sociedade Brasileira de Medicina Tropical · 2021
Analysis of annexin-A1 in the macrophages and apoptotic cells of patients with cutaneous leishmaniasis.
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Pona Mariana Nascimento, Dietrich Jordhana Mendonça, Silva Joselina Maria da, Silva Helen Aguiar Lemes da, Hueb Marcia, Damazo Amilcar Sabino
Аннотация
INTRODUCTION: This study aimed to determine the number of macrophages and apoptotic cells and perform annexin-A1 detection in patients with leishmaniasis.
METHODS: Patients with Leishmania infection were admitted to Júlio Müller University Hospital.
RESULTS: The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction.
CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis.
METHODS: Patients with Leishmania infection were admitted to Júlio Müller University Hospital.
RESULTS: The number of apoptotic cells was higher in the exudative granulomatous reaction. The exudative cellular reaction displayed higher levels of annexin-A1 detection in macrophages and apoptotic cells. The correlation between annexin-A1 detection in apoptotic cells and macrophages was observed in exudative necrotic reaction and exudative necrotic-granulomatous reaction.
CONCLUSIONS: Our data demonstrate the relevance of annexin-A1 in the regulation of apoptosis and phagocytosis in leishmaniasis.