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Ocular immunology and inflammation · 2020

Clinical Characteristics, Management, and Factors Associated with Poor Visual Prognosis of Acute Retinal Necrosis.

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Takase Hiroshi, Goto Hiroshi, Namba Kenichi, Mizuki Nobuhisa, Okada Annabelle A, Ohguro Nobuyuki, Sonoda Koh-Hei, Tomita Makoto, Keino Hiroshi, Kezuka Takeshi, Kubono Reo, Mizuuchi Kazuomi, Shibuya Etsuko, Takahashi Hiroyuki, Yanai Ryoji, Mochizuki Manabu, Japan ARN Study Group

Аннотация

Purpose: To identify the clinical characteristics of acute retinal necrosis (ARN) and clarify factors associated with poor visual prognosis.Methods: a nationwide multi-center retrospective chart review study was performed in Japan using data from the medical records of 149 consecutive ARN patients. Demographics, ocular signs, virologic testing of intraocular fluids, and treatment were examined. Factors associated with poor visual prognosis were investigated by regression analysis.Results: At initial presentation, anterior chamber cells or mutton-fat keratic precipitates (97%), unilaterality (93%), and yellow-white retinal lesions (86%) were recognized. In the clinical course, rapid circumferential expansion of retinal lesions (39%), development of retinal break or retinal detachment (55%), and optic atrophy (43%) were recorded. Four variables were identified as associated with poor visual prognosis.Conclusions: The present study identified clinical characteristics and factors associated with poor visual prognosis of ARN.

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