Molecules (Basel, Switzerland) · 2020
The Effect of Different Water Extracts from Platycodon grandiflorum on Selected Factors Associated with Pathogenesis of Chronic Bronchitis in Rats.
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Buchwald Waldemar, Szulc Michał, Baraniak Justyna, Derebecka Natalia, Kania-Dobrowolska Małgorzata, Piasecka Anna, Bogacz Anna, Karasiewicz Monika, Bartkowiak-Wieczorek Joanna, Kujawski Radosław, Gryszczyńska Agnieszka, Kachlicki Piotr, Dreger Mariola, Ożarowski Marcin, Krajewska-Patan Anna, Górska-Paukszta Małgorzata, Kamińska Ewa, Mikołajczak Przemysław Ł
Аннотация
The aim of this study was to assess the activity of extracts from Platycodon grandiflorum A. DC (PG) in a model of chronic bronchitis in rats. The research was carried out on three water extracts: E1 - from roots of field cultivated PG; E2 - from biotransformed roots of PG; E3 - from callus of PG. The extracts differed in saponins and inulin levels-the highest was measured in E3 and the lowest in E1. Identification of secondary metabolites was performed using two complementary LC-MS systems. Chronic bronchitis was induced by sodium metabisulfite (a source of SO2). Animals were treated with extracts for three weeks (100 mg/kg, intragastrically) and endothelial growth factor (VEGF), transforming growth factors (TGF-β1, -β2, -β3), and mucin 5AC (MUC5AC) levels were determined in bronchoalveolar lavage fluid, whereas C reactive protein (CRP) level was measured in serum. Moreover, mRNA expression were assessed in bronchi and lungs. In SO2-exposed rats, an elevation of the CRP, TGF-β1, TGF-β2, VEGF, and mucin was found, but the extracts' administration mostly reversed this phenomenon, leading to control values. The results showed a strong anti-inflammatory effect of the extracts from PG.