Short Tandem Repeat 3D Structure Database (STR3SD): A Resource for Structural Biology Research of Short Tandem Repeats in Neurodegenerative Disorders.

The Short Tandem Repeat 3D Structure Database (STR3SD) is a web-based database that provides a comprehensive resource for structural biology research of short tandem repeats (STRs) in cancers and neurodegenerative diseases. STR3SD contains three-dimensional (3D) structures of STRs surveyed from literature. The data are organized into three main categories, including 3D structures of nucleic acids only, nucleic acids-protein complexes, and nucleic acids-ligand complexes. Under these categories, each entry is annotated with repeat type, molecular type (DNA or RNA), sequence, PDB ID, structural component, ligand name, structural determination method, experimental conditions (temperature, pH, and ion), PubMed ID, and interactive 3D structure view. The database is built on direct literature investigation by human experts and serves as a crucial tool for studying structures and functions of STRs in cancers and neurodegenerative diseases, supporting research on structural polymorphisms and pathogenic mechanisms of STRs, and facilitating drug design targeting STRs for disease therapy.