[Rinsho ketsueki] The Japanese journal of clinical hematology · 2022
[HLA-haploidentical peripheral blood stem cell transplantation with post-transplantation cyclophosphamide for adult T-cell leukemia].
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Ishii Keitaro, Okamoto Sho, Fujita Mai, Sugihara Ayano, Nagaie Toshiaki, Nishioka Atsujiro, Kamachi Kazuharu, Itamura Hidekazu, Katsuya Hiroo, Yoshimura Mariko, Ureshino Hiroshi, Ando Toshihiko, Kubota Yasushi, Kimura Shinya
Аннотация
Recently, allogeneic peripheral blood stem cell transplantation from human leukocyte antigen (HLA)-haploidentical donors using post-transplantation cyclophosphamide (PTCY-haploPBSCT) has become available in clinical practice. However, the efficacy of PTCY in adult T-cell leukemia (ATL) is not fully established yet. In this study, we retrospectively examined data of seven patients who underwent PTCY-haploPBSCT. The overall survival rate at 100 days after transplantation was 85.7%, and the 1-year overall survival rate was 68.6%. The cumulative incidence of relapse at 1 year was 31.4%, whereas the 1-year nonrelapse mortality was 17.1%. The cumulative incidence of grade III-IV acute graft-versus-host disease (GVHD) on day 100 was 14.3%, and the incidence of chronic GVHD at 1 year was 33.3%. These results suggest that PTCY-haploPBSCT can be a viable option even in patients with ATL. Further accumulation of knowledge and improvement of transplantation outcomes are warranted in the future.