Revista da Sociedade Brasileira de Medicina Tropical · 2012
Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis.
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Neves Elizabeth de Souza, Curi André Luis Land, Albuquerque Maira Cavalcanti de, Palhano-Silva Cassius Schnel, Silva Laura Berriel da, Bueno Wendy Fernandes, Amendoeira Maria Regina Dos Reis, Bonecini-Almeida Maria da Gloria, Fernandes Octavio
Аннотация
INTRODUCTION: A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis.
METHODS: A case-control study was conducted among 30 patients and 90 controls.
RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease.
CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
METHODS: A case-control study was conducted among 30 patients and 90 controls.
RESULTS: Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease.
CONCLUSIONS: Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.