Indian journal of psychiatry · 2025
Ketamine's double-edged sword: Therapeutic benefits and adverse events in adolescent treatment-resistant OCD - A case series.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kumar Suparna, Pattnaik Jigyansa Ipsita, Panda Udit Kumar, Dixit Tanya, Srivastava Aashi, Pal Shounak, Acharya Bhagyashree, Gulati Meghal, Ravan Jayaprakash Russell
Аннотация
BACKGROUND: About one-third of obsessive-compulsive disorder (OCD) cases show poor response to first-line treatments. Ketamine's role in modulating glutamate, implicated in OCD pathogenesis, warrants investigation.
CASES: Four adolescents with treatment-resistant OCD received ketamine infusion (0.5 mg/kg) every other day for six sessions with monitoring using the Children's Yale-Brown Obsessive Compulsive Scale (C-YBCOS) and Clinician-Administered Dissociative State Scale (CADSS). Three patients showed progressive improvement after multiple infusions with maintained benefits at 2-month follow-up. One patient developed ketamine-induced psychosis.
CONCLUSION: Ketamine shows promise as adjuvant treatment in adolescent OCD, though psychomimetic risks require careful consideration.
CASES: Four adolescents with treatment-resistant OCD received ketamine infusion (0.5 mg/kg) every other day for six sessions with monitoring using the Children's Yale-Brown Obsessive Compulsive Scale (C-YBCOS) and Clinician-Administered Dissociative State Scale (CADSS). Three patients showed progressive improvement after multiple infusions with maintained benefits at 2-month follow-up. One patient developed ketamine-induced psychosis.
CONCLUSION: Ketamine shows promise as adjuvant treatment in adolescent OCD, though psychomimetic risks require careful consideration.