Prevalence of PPNG strains & in vitro sensitivity pattern of Neisseria gonorrhoeae in Varanasi (Uttar Pradesh, India).

Forty one consecutive gonococcal isolates were tested by disc method for their sensitivity to penicillin and seven other antimicrobials. Nineteen (46.34%) strains of N. gonorrhoeae were found to be relatively resistant to penicillin (MIC over 0.25 IU/ml) including 2 (4.88%) strains with complete resistance to penicillin (MIC over 1 IU/ml). None of the gonococcal strains tested was penicillinase-producing (PPNG). A decline in the proportion of sensitive strains of gonococci with a non-significant rise in median value of MIC for penicillin from 2.16 IU/ml in 1980-81 to 2.52 IU/ml in 1986-87 and other antimicrobials was observed.