Epidemiology and Antibiotic Resistance Patterns of Klebsiella pneumoniae Infections Among Male Patients in a Long-Term Care Hospital in Riyadh, Saudi Arabia: A Retrospective Study.

BACKGROUND

Klebsiella pneumoniae is an opportunistic pathogen commonly found in the normal flora of the gastrointestinal tract. While it typically remains benign, it can lead to severe healthcare-associated infections, particularly among immunocompromised individuals and those in long-term care settings. This study aimed to investigate the epidemiology and antibiotic resistance patterns of K. pneumoniae infections among male patients in a long-term care hospital.

METHODS

A retrospective cross-sectional study was conducted, analyzing microbial culture data from 29 male patients admitted to the male ward of a long-term care hospital in Riyadh, Saudi Arabia. The study included patients with confirmed positive cultures for K. pneumoniae. Data were collected regarding demographic information, culture sites, and antibiotic susceptibility test results. Statistical analysis was performed to identify significant associations between patient characteristics and resistance patterns, with a particular focus on the prevalence of carbapenem-resistant Enterobacterales (CRE) and the production of extended-spectrum beta-lactamases (ESBL).

RESULTS

Around 51.7% of the K. pneumoniae isolates were found to be resistant to carbapenems, while 24.1% were classified as producers of ESBL. Patients suffering from bedsores had a significantly higher prevalence of CRE infections at 37.9% compared to only 13.8% in patients without bedsores (p=0.034). The analysis also indicated that older patients (aged over 50 years) exhibited a higher prevalence of CRE infections (34.5%) compared to their younger counterparts (17.2%, p=0.069). Notably, resistance levels against antibiotics were high, with 75.9% of isolates resistant to cotrimoxazole, 65.5% to ciprofloxacin, and 62.1% to gentamicin. In contrast, imipenem and meropenem showed relatively higher susceptibility, with each antibiotic having a susceptibility rate of 34.5%.

CONCLUSION

There is a significant prevalence of multidrug-resistant K. pneumoniae infections in long-term care environments, particularly affecting older male patients and those with bedsores. These findings underscore the need for targeted infection control measures and enhanced antibiotic stewardship programs. Future research should include both genders to investigate epidemiological differences and broader resistance trends.