Nature biomedical engineering · 2022
A strain-programmed patch for the healing of diabetic wounds.
СтатьяПоддержка исследования: вне правительства СШАПоддержка правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Theocharidis Georgios, Yuk Hyunwoo, Roh Heejung, Wang Liu, Mezghani Ikram, Wu Jingjing, Kafanas Antonios, Contreras Mauricio, Sumpio Brandon, Li Zhuqing, Wang Enya, Chen Lihong, Guo Chuan Fei, Jayaswal Navin, Katopodi Xanthi-Leda, Kalavros Nikolaos, Nabzdyk Christoph S, Vlachos Ioannis S, Veves Aristidis, Zhao Xuanhe
Аннотация
Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with bioengineered skin or with growth factors. However, most patients do not benefit from these treatments. Here we report the development and preclinical therapeutic performance of a strain-programmed patch that rapidly and robustly adheres to diabetic wounds, and promotes wound closure and re-epithelialization. The patch consists of a dried adhesive layer of crosslinked polymer networks bound to a pre-stretched hydrophilic elastomer backing, and implements a hydration-based shape-memory mechanism to mechanically contract diabetic wounds in a programmable manner on the basis of analytical and finite-element modelling. In mouse and human skin, and in mini-pigs and humanized mice, the patch enhanced the healing of diabetic wounds by promoting faster re-epithelialization and angiogenesis, and the enrichment of fibroblast populations with a pro-regenerative phenotype. Strain-programmed patches might also be effective for the treatment of other forms of acute and chronic wounds.