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Войти в исследования International journal of clinical pharmacology and therapeutics · 2026
Determination of antimicrobial resistance pattern among post-operative orthopedic implant patients in a tertiary care hospital: A retrospective study.
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Nazeer Hajira, Khan Humaira Majeed, Hannan Muhammad Abdul, Zulfiqar Sadaf, Gul Bazgha, Alhomrani Majid, Alamri Abdulhakeem S, Alsanie Walaa F, Usman Muhammad
Аннотация
BACKGROUND: The misuse of antibiotics leads to antimicrobial resistance, particularly concerning infections related to orthopedic implants. The aim of this study was to determine the sensitivity pattern of bacterial isolates in patients with orthopedic implants having infections.
MATERIALS AND METHODS: A retrospective cross-sectional study was conducted at Ghurki Trust Teaching Hospital, Lahore. Culture sensitivity reports from 548 patients were collected between January 2020 and March 2023. Patient demographics, including age, sex, culture specimens (blood, wound, etc.), and antibiotic sensitivity were recorded.
RESULTS: Seven types of implants were analyzed, with Ilizarov (25.5%) being the most infected external implant and nails (24.7%) the most infected internal implant. The study included 10 clinically significant bacteria, with Staphylococcus aureus (n = 195, 35.5%) being the most common Gram-positive pathogen, and Escherichia coli (n = 99, 18.0%) being the most prevalent Gram-negative pathogen. A total of 40 antibiotics were tested; amoxicillin was the least effective, whereas linezolid, vancomycin, and fosfomycin showed the highest efficacy against all implant-related infections included in this study.
CONCLUSION: The critical challenges of antimicrobial resistance in orthopedic implant-related infections have been highlighted. Urgent institutional and policy level interventions are required for implementation of stringent infection control protocols and robust antibiotic stewardship programs to prevent a post-antibiotic crisis.
MATERIALS AND METHODS: A retrospective cross-sectional study was conducted at Ghurki Trust Teaching Hospital, Lahore. Culture sensitivity reports from 548 patients were collected between January 2020 and March 2023. Patient demographics, including age, sex, culture specimens (blood, wound, etc.), and antibiotic sensitivity were recorded.
RESULTS: Seven types of implants were analyzed, with Ilizarov (25.5%) being the most infected external implant and nails (24.7%) the most infected internal implant. The study included 10 clinically significant bacteria, with Staphylococcus aureus (n = 195, 35.5%) being the most common Gram-positive pathogen, and Escherichia coli (n = 99, 18.0%) being the most prevalent Gram-negative pathogen. A total of 40 antibiotics were tested; amoxicillin was the least effective, whereas linezolid, vancomycin, and fosfomycin showed the highest efficacy against all implant-related infections included in this study.
CONCLUSION: The critical challenges of antimicrobial resistance in orthopedic implant-related infections have been highlighted. Urgent institutional and policy level interventions are required for implementation of stringent infection control protocols and robust antibiotic stewardship programs to prevent a post-antibiotic crisis.