Медицинская библиотека · Oral diseases · 1999

p53 and MDM2 expression in odontogenic cysts and tumours.

Carvalhais J, Aguiar M, Araújo V, Araújo N, Gomez R

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Аннотация

OBJECTIVE

The aim of this report was to assess p53 and MDM2 expression in odontogenic cysts and tumours, as they are known to play important roles in cell proliferation and tumorigenesis.

MATERIALS AND

METHODS

The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin-fixed, paraffin embedded specimens of odontogenic cysts and tumours.

RESULTS

No positivity to p53 was found in the cases studied. MDM2 expression in ameloblastoma was higher than in radicular cysts, but lower than that observed in odontogenic keratocysts. No difference was observed between MDM2 expression in radicular cyst and adenomatoid odontogenic tumour. The clear-cell odontogenic ameloblastoma presented strong immunoreaction to this antigen.

CONCLUSIONS

The results suggest that MDM2 overexpression may be involved in the pathogenesis of some odontogenic lesions.

Для цитирования: Carvalhais J, Aguiar M, Araújo V, Araújo N, Gomez R. p53 and MDM2 expression in odontogenic cysts and tumours.. Oral diseases. 1999. DOI: 10.1111/j.1601-0825.1999.tb00304.x.

Предметные рубрики MeSH

Gene Expression Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Neoplasm Proteins Nuclear Proteins Odontogenic Cysts Odontogenic Tumors Proto-Oncogene Proteins Proto-Oncogene Proteins c-mdm2 Tumor Suppressor Protein p53 Up-Regulation

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