eLife · 2020
Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Malacco Nathalia Luisa Sousa de Oliveira, Souza Jessica Amanda Marques, Martins Flavia Rayssa Braga, Rachid Milene Alvarenga, Simplicio Janaina Aparecida, Tirapelli Carlos Renato, Sabino Adriano de Paula, Queiroz-Junior Celso Martins, Goes Grazielle Ribeiro, Vieira Leda Quercia, Souza Danielle Glória, Pinho Vanessa, Teixeira Mauro Martins, Soriani Frederico Marianetti
Аннотация
Chronic ethanol consumption is a leading cause of mortality worldwide, with higher risks to develop pulmonary infections, including Aspergillus infections. Mechanisms underlying increased susceptibility to infections are poorly understood. Chronic ethanol consumption induced increased mortality rates, higher Aspergillus fumigatus burden and reduced neutrophil recruitment into the airways. Intravital microscopy showed decrease in leukocyte adhesion and rolling after ethanol consumption. Moreover, downregulated neutrophil activation and increased levels of serum CXCL1 in ethanol-fed mice induced internalization of CXCR2 receptor in circulating neutrophils. Bone marrow-derived neutrophils from ethanol-fed mice showed lower fungal clearance and defective reactive oxygen species production. Taken together, results showed that ethanol affects activation, recruitment, phagocytosis and killing functions of neutrophils, causing susceptibility to pulmonary A. fumigatus infection. This study establishes a new paradigm in innate immune response in chronic ethanol consumers.