Predictive factors for disseminated intravascular coagulation following colorectal perforation.

PURPOSE: To determine the relationship between postoperative disseminated intravascular coagulation (DIC) and patient prognosis after surgery for colorectal perforation and to identify preoperative predictive factors for DIC.

METHODS

We included 112 patients who underwent emergency surgery for colorectal perforation between April 2014 and September 2023. We performed a Kaplan-Meier analysis to assess 30-day postoperative survival with and without postoperative DIC, log-rank test to compare survival curves, and logistic regression analysis to identify preoperative predictive factors for postoperative DIC.

RESULTS

The postoperative DIC and 30-day mortality rates were 37.5 ​% and 8 ​%, respectively. The 30-day postoperative mortality rates significantly differed between patients with postoperative DIC and those without (16.7 ​% vs. 2.9 ​%). The preoperative Sequential Organ Failure Assessment (SOFA) score was an independent predictive factor for postoperative DIC.

CONCLUSION

Evaluating preoperative SOFA scores may help assess postoperative DIC risk and enable early initiation of anticoagulant therapy in patients undergoing surgery for colorectal perforation.