International ophthalmology · 2025
Dry eye after photorefractive keratectomy (PRK) and transepithelial photorefractive keratectomy (T-PRK): a comparative clinical study.
СтатьяНаблюдательное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zarei-Ghanavati Siamak, Sadeghi Javad, Hassanzadeh Samira, Shayan Far Mahdieh, Heravian Shandiz Javad, Jamali Jamshid, Abbasi Mehrabadi Ali, Irandoost Niloofar, Aryanmanesh Sina, Gharouni Ahmad, Varshovi-Jaghargh Iman
Аннотация
PURPOSE: To compare dry eye disease (DED) following PRK and T-PRK surgeries using a combined approach of subjective and objective measures, focusing on clinically meaningful outcomes and adjusted statistical modeling.
METHODS: In this prospective observational study, 89 eyes of patients aged over 20 years were enrolled and grouped into PRK (43 eyes) and T-PRK (46 eyes). The primary outcome was change in ocular surface diseases index (OSDI) score at 6 months. Secondary outcomes included non-invasive tear breakup time (NITBUT) and meibomian gland expressibility. Exploratory parameters such as tear meniscus height (TMH), redness score, strip meniscometry (SM Tube), meibomian gland dropout, and meibum quality were also assessed. Statistical models were adjusted for baseline age differences, and corrections for multiple comparisons were applied.
RESULTS: The mean age of the patients was 34.16 ± 7.23 in the PRK and 28.72 ± 6.26 in the T-PRK group (P < 0.001). The two groups were not significantly different for gender (P = 0.367). After statistical adjustment, only the change in OSDI and NITBUT at 1-month remained significant between groups (adjusted P = 0.038 and P < 0.05, respectively). Effect sizes were small to moderate, and none of the differences exceeded minimal clinically important thresholds. Exploratory analyses revealed no significant between-groups differences. Age was identified as an independent predictor of OSDI change.
CONCLUSION: In short-term follow-up, both procedures induced some degree of DED. However, T-PRK was associated with slightly fewer signs and symptoms of dry eye disease, but the differences were not clinically significant.
METHODS: In this prospective observational study, 89 eyes of patients aged over 20 years were enrolled and grouped into PRK (43 eyes) and T-PRK (46 eyes). The primary outcome was change in ocular surface diseases index (OSDI) score at 6 months. Secondary outcomes included non-invasive tear breakup time (NITBUT) and meibomian gland expressibility. Exploratory parameters such as tear meniscus height (TMH), redness score, strip meniscometry (SM Tube), meibomian gland dropout, and meibum quality were also assessed. Statistical models were adjusted for baseline age differences, and corrections for multiple comparisons were applied.
RESULTS: The mean age of the patients was 34.16 ± 7.23 in the PRK and 28.72 ± 6.26 in the T-PRK group (P < 0.001). The two groups were not significantly different for gender (P = 0.367). After statistical adjustment, only the change in OSDI and NITBUT at 1-month remained significant between groups (adjusted P = 0.038 and P < 0.05, respectively). Effect sizes were small to moderate, and none of the differences exceeded minimal clinically important thresholds. Exploratory analyses revealed no significant between-groups differences. Age was identified as an independent predictor of OSDI change.
CONCLUSION: In short-term follow-up, both procedures induced some degree of DED. However, T-PRK was associated with slightly fewer signs and symptoms of dry eye disease, but the differences were not clinically significant.