Diseases (Basel, Switzerland) · 2026
Long-Term Survival with Daratumumab, Lenalidomide and Dexamethasone in Transplant-Ineligible Newly Diagnosed Multiple Myeloma Patients-A Survey from Two Italian Centers.
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Del Fabro Vittorio, Gullo Lara, Giunta Giuliana, Uccello Giuseppina, Bellofiore Claudia, Lo Faro Cristina, Leotta Dario, Elia Federica, Vecchio Veronica, Sorbello Chiara, Consoli Ugo, Romano Alessandra, Di Raimondo Francesco, Fazio Manlio, Stagno Fabio, Conticello Concetta
Аннотация
BACKGROUND: Multiple myeloma (MM) is a clonal plasma cell neoplasm representing the second most common hematological malignancy. The combination of daratumumab, lenalidomide and dexamethasone (D-Rd) was first approved by the EMA (European Medicines Agency) for the treatment of relapsed/refractory multiple myeloma (RRMM) patients, and was subsequently approved for first-line therapy, based on the results of POLLUX and MAIA trials, respectively.
METHODS: In this survey, we retrospectively collected data from 96 consecutive transplant-ineligible newly diagnosed multiple myeloma (TIE-NDMM) patients treated with the D-Rd combination.
RESULTS: The median age was 73 years; the median progression free survival (mPFS) and median overall survival (mOS) were not reached (NR); the overall response rate (ORR), defined as patients who obtained at least a partial response (PR), was 90%; 59% of patients achieved a very good partial response (VGPR) or better. A strong negative correlation was observed between treatment response and elevated beta-2-microglobulin levels.
CONCLUSIONS: This study confirms the efficacy of the D-Rd combination as first-line therapy for TIE-NDMM patients, suggesting that achieving at least a PR-and particularly a VGPR-may represent a strong predictor of long-term remission and survival, even in the era of new combinations based on the use of quadruplets.
METHODS: In this survey, we retrospectively collected data from 96 consecutive transplant-ineligible newly diagnosed multiple myeloma (TIE-NDMM) patients treated with the D-Rd combination.
RESULTS: The median age was 73 years; the median progression free survival (mPFS) and median overall survival (mOS) were not reached (NR); the overall response rate (ORR), defined as patients who obtained at least a partial response (PR), was 90%; 59% of patients achieved a very good partial response (VGPR) or better. A strong negative correlation was observed between treatment response and elevated beta-2-microglobulin levels.
CONCLUSIONS: This study confirms the efficacy of the D-Rd combination as first-line therapy for TIE-NDMM patients, suggesting that achieving at least a PR-and particularly a VGPR-may represent a strong predictor of long-term remission and survival, even in the era of new combinations based on the use of quadruplets.