Micronized acellular dermal matrix combined with platelet rich plasma in the treatment of atrophic acne scars: A self-controlled split face study.

BACKGROUND

Micronized acellular dermal matrix (mADM) can induce tissue regeneration and repair, and filling.

OBJECTIVES

The efficacy and safety of (mADM) were evaluated in the treatment of atrophic acne scar.

METHODS

In this single-blinded, self-controlled, split-face study, 16 patients (48 scar sites) were divided into treatment group (24 scar sites) and control group (24 scar sites). One side of the affected area was treated with mADM combined with platelet rich plasma (PRP) injection as the treatment group; the other side of the affected area was treated with PRP injection as the control group. The efficacy was evaluated by the Acne scar assessment scale (ASAS) and Acne Scar Weight Rating Scale (ECCA) 3 months after treatment.

RESULTS

After 3-month treatment in 16 patients, the atrophic acne scars in both groups were all improved. The ASAS score and ECCA weight score in the treatment group was significantly lower than that in the control group (2.50 ± 0.51 vs. 3.62 ± 0.77 and 14.17 ± 10.18 vs. 31.88 ± 13.25; p < 0.001).

LIMITATIONS: Short-term 3-month treatment period. Small sample size limits generalizability of results.

CONCLUSION

The curative effect of mADM combined with PRP is significantly better than that of PRP alone.