Leukocytoclastic vasculitis following staphylococcal protein A column immunoadsorption therapy for idiopathic thrombocytopenic purpura.

A patient with refractory idiopathic thrombocytopenic purpura developed widespread palpable purpura, fever, diarrhea, and arthralgias forty-eight hours following a third protein A immunoadsorption treatment. A skin biopsy revealed leukocytoclastic vasculitis. His skin lesions and constitutional symptoms resolved with administration of antibiotics and bed rest.