[Effect of lysine, threonine, methionine and vitamin A, C and E deficiency on the liver microsome enzyme system responsible for metabolizing foreign compounds in the rat].

It has been demonstrated that the deficiency of 3 essential amino acids (lysine, threonine and methionine) combined with polyhypovitaminosis A, C and E for 2 months leads to a decrease in the para-hydroxylase and N-demethylase activity in rat liver microsomes. The content of cytochromes P-450 and b5 was also reduced as compared to that in animals given balanced nutrition. However, in such a polynutrient deficiency, the activity of microsomal enzymes was induced by phenobarbital to a greater degree than in balanced nutrition. It is suggested that in polynutrient deficiency, the lacking essential factors mobilized from other organs and tissues are involved in the process of induction of microsomal enzymes.