The Journal of nutrition · 2025
Dietary Polyphenols and Inflammatory Markers in Rural Adult Women in Puno, Peru.
СтатьяРандомизированное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Laveriano-Santos Emily P, Tarazona-Meza Carla, Malpartida Gary, Barr Dana B, Williams Kendra N, Kephart Josiah L, Nicolaou Laura, Fandiño-Del-Rio Magdalena, Simkovich Suzanne, Chiang Marilu, Koehler Kirsten, Lamuela-Raventós Rosa M, Checkley William, Cardiopulmonary Outcomes and Household Air Pollution (CHAP) trial investigators
Аннотация
BACKGROUND: Dietary polyphenols are bioactive compounds credited with health protection and reducing inflammation. Evidence on their effects is limited in low- and middle-income countries, especially among rural populations.
OBJECTIVES: To evaluate the association between dietary polyphenols intake and markers of inflammation and endothelial adhesion over 12 mo of follow-up among rural adult women participating in the Cardiopulmonary Outcomes and Household Air Pollution randomized controlled trial.
METHODS: We used data at baseline and 12-mo visit in 100 healthy women aged 25-64 y living in rural communities in Puno, Peru. We assessed dietary intake using 24-h dietary recalls and measured inflammatory cytokines [interleukin (IL)-10, IL-6, IL-1β, C-reactive protein, tumor necrosis factor-α] and endothelial adhesion (vascular cell adhesion protein-1, intercellular adhesion molecule-1) biomarkers in dried blood spots using immunoassay analyses. We quantified polyphenol intake using the Phenol-Explorer database. We used multivariable linear regression to assess the association between changes (12-mo of follow-up minus baseline) in dietary polyphenols intake, and inflammatory and endothelial adhesion markers at 12-mo.
RESULTS: At baseline, mean (±standard deviation) participant age was 49 ± 10 y, mean total polyphenol intake was 335 ± 193 mg/d, and mean phenolic acids intake was 195 ± 80 mg/d. Lower IL-1β concentrations at 12-mo were associated with higher energy-adjusted phenolic acid intake [adjusted mean difference -0.35 pg/mL per mg/d; 95% confidence interval (CI): -0.63, -0.07]. In contrast, higher anti-inflammatory cytokines IL-10 concentrations at 12 mo were associated with higher energy-adjusted intake of stilbenes (0.42 pg/mL per mg/d; 95% CI: 0.18, 0.66) and other polyphenols (0.28 pg/mL per mg/d; 95% CI: 0.10, 0.46).
CONCLUSIONS: Higher polyphenol intake, particularly phenolic acids and stilbenes, was associated with an improved anti-inflammatory profile in rural women.
OBJECTIVES: To evaluate the association between dietary polyphenols intake and markers of inflammation and endothelial adhesion over 12 mo of follow-up among rural adult women participating in the Cardiopulmonary Outcomes and Household Air Pollution randomized controlled trial.
METHODS: We used data at baseline and 12-mo visit in 100 healthy women aged 25-64 y living in rural communities in Puno, Peru. We assessed dietary intake using 24-h dietary recalls and measured inflammatory cytokines [interleukin (IL)-10, IL-6, IL-1β, C-reactive protein, tumor necrosis factor-α] and endothelial adhesion (vascular cell adhesion protein-1, intercellular adhesion molecule-1) biomarkers in dried blood spots using immunoassay analyses. We quantified polyphenol intake using the Phenol-Explorer database. We used multivariable linear regression to assess the association between changes (12-mo of follow-up minus baseline) in dietary polyphenols intake, and inflammatory and endothelial adhesion markers at 12-mo.
RESULTS: At baseline, mean (±standard deviation) participant age was 49 ± 10 y, mean total polyphenol intake was 335 ± 193 mg/d, and mean phenolic acids intake was 195 ± 80 mg/d. Lower IL-1β concentrations at 12-mo were associated with higher energy-adjusted phenolic acid intake [adjusted mean difference -0.35 pg/mL per mg/d; 95% confidence interval (CI): -0.63, -0.07]. In contrast, higher anti-inflammatory cytokines IL-10 concentrations at 12 mo were associated with higher energy-adjusted intake of stilbenes (0.42 pg/mL per mg/d; 95% CI: 0.18, 0.66) and other polyphenols (0.28 pg/mL per mg/d; 95% CI: 0.10, 0.46).
CONCLUSIONS: Higher polyphenol intake, particularly phenolic acids and stilbenes, was associated with an improved anti-inflammatory profile in rural women.