Prolactin and thyrotropin response to thyrotropin-releasing-hormone in adolescent females with insulin-treated diabetes mellitus.

Prolactin and thyrotropin response to TRH and basal gonadotropins levels in blood were investigated in insulin-treated adolescent females with regular menstruation cycles (Group I) and menstruation disturbances (Group II) compared with control, healthy girls. No significant differences were found in TSH secretion after TRH administration and basal LH, FSH levels between the observed groups. Blood basal PRL levels were significantly lower in young females in Group II, and a highly increased mobilization of PRL secretion (delta % PRL)--masked hyperprolactinaemia--in all of the groups of diabetic girls was revealed. Cytological examination of vaginal smears confirmed hypoestrogenic status of girls from Group II compared with Group I and the control group.