Journal of clinical immunology · 2010
B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease.
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mouillot Gaël, Carmagnat Maryvonnick, Gérard Laurence, Garnier Jean-Luc, Fieschi Claire, Vince Nicolas, Karlin Lionel, Viallard Jean-François, Jaussaud Roland, Boileau Julien, Donadieu Jean, Gardembas Martine, Schleinitz Nicolas, Suarez Felipe, Hachulla Eric, Delavigne Karen, Morisset Martine, Jacquot Serge, Just Nicolas, Galicier Lionel, Charron Dominique, Debré Patrice, Oksenhendler Eric, Rabian Claire, DEFI Study Group
Аннотация
BACKGROUND: Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by recurrent infections and defective immunoglobulin production.
METHODS: The DEFI French national prospective study investigated peripheral T-cell and B-cell compartments in 313 CVID patients grouped according to their clinical phenotype, using flow cytometry.
RESULTS: In patients developing infection only (IO), the main B-cell or T-cell abnormalities were a defect in switched memory B cells and a decrease in naive CD4(+) T cells associated with an increase in CD4(+)CD95(+) cells. These abnormalities were more pronounced in patients developing lymphoproliferation (LP), autoimmune cytopenia (AC), or chronic enteropathy (CE). Moreover, LP and AC patients presented an increase in CD21(low) B cells and CD4(+)HLA-DR(+) T cells and a decrease in regulatory T cells.
CONCLUSION: In these large series of CVID patients, the major abnormalities of the B-cell and T-cell compartments, although a hallmark of CVID, were only observed in half of the IO patients and were more frequent and severe in patients with additional lymphoproliferative, autoimmune, and digestive complications.
METHODS: The DEFI French national prospective study investigated peripheral T-cell and B-cell compartments in 313 CVID patients grouped according to their clinical phenotype, using flow cytometry.
RESULTS: In patients developing infection only (IO), the main B-cell or T-cell abnormalities were a defect in switched memory B cells and a decrease in naive CD4(+) T cells associated with an increase in CD4(+)CD95(+) cells. These abnormalities were more pronounced in patients developing lymphoproliferation (LP), autoimmune cytopenia (AC), or chronic enteropathy (CE). Moreover, LP and AC patients presented an increase in CD21(low) B cells and CD4(+)HLA-DR(+) T cells and a decrease in regulatory T cells.
CONCLUSION: In these large series of CVID patients, the major abnormalities of the B-cell and T-cell compartments, although a hallmark of CVID, were only observed in half of the IO patients and were more frequent and severe in patients with additional lymphoproliferative, autoimmune, and digestive complications.
Предметные рубрики MeSH
AdultAgedB-LymphocytesCD4 AntigensCell SeparationCommon Variable ImmunodeficiencyDisease ProgressionFemaleFlow CytometryFranceHumansImmunoglobulin Class SwitchingImmunologic MemoryImmunophenotypingInfectionsLymphocyte SubsetsLymphopeniaMaleMiddle AgedProtein-Losing EnteropathiesT-Lymphocytesfas Receptor