Cholangiocarcinoma associated with liver fluke infection: a preventable source of morbidity in Asian immigrants.

In the Far East infection with the liver flukes Clonorchis sinensis and Opisthorchis viverrini is the most frequently documented cause of cholangiocarcinoma. Liver fluke infection in the United States remains a health problem for more than 500,000 Southeast Asian refugees who have immigrated to this country since 1975. Recent surveys have revealed that up to 26% of Asian immigrants have an active liver fluke infection. However, the common clinical manifestations of this condition, as well as the possibility of developing such long-term sequelae as cholangiocarcinoma, remain unknown to many physicians providing care for this population. This report describes a clinically unsuspected C. sinensis infection associated with cholangiocarcinoma in an elderly Chinese immigrant, and emphasizes the importance of early diagnosis and treatment of all liver fluke infections in the prevention of bile duct neoplasms in high risk populations.