[Microfilters within the scope of infusion therapy--possibilities and problems in retention of microbial and particle contaminants].

Contamination of parenterally applied fluids by bacterial and particulate material may contribute to the development of sepsis, multiple organ failure, and adult respiratory distress syndrome. 0.2 microns in-line filters are effective in reducing bacteria and foreign matter in the infused fluids. The rate of thrombophlebitis was demonstrated to be significantly reduced by in-line filtration. However, to date there is no definite evidence from clinical studies that these filters are effective in reducing overall morbidity and mortality. Furthermore the use of in-line filters reduces waste material and required nursing time, because the infusion systems have to be replaced every 96 hours as opposed to 24 hours without filters. In conclusion, use of 0.2 microns in-line filters in infusion therapy is cost effective and may enhance patients' safety.