Tropical medicine & international health : TM & IH · 2007
Endogenous reactivation and true treatment failure as causes of recurrent tuberculosis in a high incidence setting with a low HIV infection.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Shamputa Isdore Chola, Van Deun Armand, Salim Md Abdul Hamid, Hossain Md Anwar, Fissette Krista, de Rijk Pim, Rigouts Leen, Portaels Françoise
Аннотация
OBJECTIVE: To determine the relative frequencies of reinfection vs. reactivation or treatment failure in patients from a high tuberculosis incidence setting with a low prevalence of HIV infection.
METHOD: We performed DNA fingerprinting on serial isolates from one and multiple TB episodes from 97 retreatment patients; 35 patients had been previously cured, whereas 62 had not.
RESULTS: DNA fingerprinting patterns of recurrence Mycobacterium tuberculosis isolates of 5 of the 35 previously cured patients did not match with those of the corresponding initial isolates, indicating reinfection. We did not document reinfection during treatment. Isolates from each of the remaining 30 previously cured patients had identical DNA fingerprinting results, indicating reactivation. DNA fingerprinting patterns of isolates from the 62 patients with persistently positive sputum smears were identical, suggesting treatment failure.
CONCLUSION: These findings suggest that reinfection is not a common cause of relapse and treatment failure in this rural predominantly HIV-free population despite the high incidence of TB.
METHOD: We performed DNA fingerprinting on serial isolates from one and multiple TB episodes from 97 retreatment patients; 35 patients had been previously cured, whereas 62 had not.
RESULTS: DNA fingerprinting patterns of recurrence Mycobacterium tuberculosis isolates of 5 of the 35 previously cured patients did not match with those of the corresponding initial isolates, indicating reinfection. We did not document reinfection during treatment. Isolates from each of the remaining 30 previously cured patients had identical DNA fingerprinting results, indicating reactivation. DNA fingerprinting patterns of isolates from the 62 patients with persistently positive sputum smears were identical, suggesting treatment failure.
CONCLUSION: These findings suggest that reinfection is not a common cause of relapse and treatment failure in this rural predominantly HIV-free population despite the high incidence of TB.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAntitubercular AgentsBangladeshDNA FingerprintingDNA, BacterialDrug Resistance, Multiple, BacterialFemaleHIV InfectionsHumansIncidenceMaleMiddle AgedMycobacterium tuberculosisPolymorphism, Restriction Fragment LengthRecurrenceRural HealthTandem Repeat SequencesTreatment FailureTuberculosis, Pulmonary