[Indicators of lipid metabolism and their relation to disorders of microcirculation in diabetes mellitus].

The levels of cholesterol, triglycerides, lipoproteins (LP), lipid peroxidation products (LPP), and tissue antioxidants were determined in 49 patients with diabetes mellitus (DM), types I and II, at the stage of subcompensation. The study groups were composed of patients with stages II and III capillaroscopic changes with corresponding changes in the fundus of the eye in the form of common and proliferating stages of retinopathy. Patients with DM of both types revealed significant changes in lipid metabolism expressed in the accumulation of highly atherogenic LP, an increase in the content of cholesterol and LPP in VLDLP and LDLP against a background of a decrease in the activity of the antioxidant system. An analysis of the data obtained made it possible to assume the involvement of LPP processes in the formation of diabetic angiopathies in patients with DM of both types.