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DOI 10.1016/j.jhep.2023.02.041

Медицинская библиотека · Journal of hepatology · 2023

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries.

Razavi Homie A, Buti Maria, Terrault Norah A, Zeuzem Stefan, Yurdaydin Cihan, Tanaka Junko, Aghemo Alessio, Akarca Ulus S, Al Masri Nasser M, Alalwan Abduljaleel M, Aleman Soo, Alghamdi Abdullah S, Alghamdi Saad, Al-Hamoudi Waleed K, Aljumah Abdulrahman A, Altraif Ibrahim H, Asselah Tarik, Ben-Ari Ziv, Berg Thomas, Biondi Mia J, Blach Sarah, Braga Wornei S M, Brandão-Mello Carlos E, Brunetto Maurizia R, Cabezas Joaquin, Cheinquer Hugo, Chen Pei-Jer, Cheon Myeong-Eun, Chuang Wan-Long, Coffin Carla S, Coppola Nicola, Craxi Antonio, Crespo Javier, De Ledinghen Victor, Duberg Ann-Sofi, Etzion Ohad, Ferraz Maria Lucia G, Ferreira Paulo R A, Forns Xavier, Foster Graham R, Gaeta Giovanni B, Gamkrelidze Ivane, García-Samaniego Javier, Gheorghe Liliana S, Gholam Pierre M, Gish Robert G, Glenn Jeffrey, Hercun Julian, Hsu Yao-Chun, Hu Ching-Chih, Huang Jee-Fu, Janjua Naveed, Jia Jidong, Kåberg Martin, Kaita Kelly D E, Kamal Habiba, Kao Jia-Horng, Kondili Loreta A, Lagging Martin, Lázaro Pablo, Lazarus Jeffrey V, Lee Mei-Hsuan, Lim Young-Suk, Marotta Paul J, Navas Maria-Cristina, Naveira Marcelo C M, Orrego Mauricio, Osiowy Carla, Pan Calvin Q, Pessoa Mário G, Raimondo Giovanni, Ramji Alnoor, Razavi-Shearer Devin M, Razavi-Shearer Kathryn, Ríos-Hincapié Cielo Y, Rodríguez Manuel, Rosenberg William M C, Roulot Dominique M, Ryder Stephen D, Safadi Rifaat, Sanai Faisal M, Santantonio Teresa A, Sarrazin Christoph, Shouval Daniel, Tacke Frank, Tergast Tammo L, Villalobos-Salcedo Juan Miguel, Voeller Alexis S, Yang Hwai-I, Yu Ming-Lung, Zuckerman Eli, Polaris Observatory

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

Hepatitis D virus (HDV) infection occurs as a coinfection with hepatitis B and increases the risk of hepatocellular carcinoma, decompensated cirrhosis, and mortality compared to hepatitis B virus (HBV) monoinfection. Reliable estimates of the prevalence of HDV infection and disease burden are essential to formulate strategies to find coinfected individuals more effectively and efficiently. The global prevalence of HBV infections was estimated to be 262,240,000 in 2021. Only 1,994,000 of the HBV infections were newly diagnosed in 2021, with more than half of the new diagnoses made in China. Our initial estimates indicated a much lower prevalence of HDV antibody (anti-HDV) and HDV RNA positivity than previously reported in published studies. Accurate estimates of HDV prevalence are needed. The most effective method to generate estimates of the prevalence of anti-HDV and HDV RNA positivity and to find undiagnosed individuals at the national level is to implement double reflex testing. This requires anti-HDV testing of all hepatitis B surface antigen-positive individuals and HDV RNA testing of all anti-HDV-positive individuals. This strategy is manageable for healthcare systems since the number of newly diagnosed HBV cases is low. At the global level, a comprehensive HDV screening strategy would require only 1,994,000 HDV antibody tests and less than 89,000 HDV PCR tests. Double reflex testing is the preferred strategy in countries with a low prevalence of HBV and those with a high prevalence of both HBV and HDV. For example, in the European Union and North America only 35,000 and 22,000 cases, respectively, will require anti-HDV testing annually.

Для цитирования: Razavi Homie A, Buti Maria, Terrault Norah A, Zeuzem Stefan, Yurdaydin Cihan, Tanaka Junko, Aghemo Alessio, Akarca Ulus S, Al Masri Nasser M, Alalwan Abduljaleel M, Aleman Soo, Alghamdi Abdullah S, Alghamdi Saad, Al-Hamoudi Waleed K, Aljumah Abdulrahman A, Altraif Ibrahim H, Asselah Tarik, Ben-Ari Ziv, Berg Thomas, Biondi Mia J, Blach Sarah, Braga Wornei S M, Brandão-Mello Carlos E, Brunetto Maurizia R, Cabezas Joaquin, Cheinquer Hugo, Chen Pei-Jer, Cheon Myeong-Eun, Chuang Wan-Long, Coffin Carla S, Coppola Nicola, Craxi Antonio, Crespo Javier, De Ledinghen Victor, Duberg Ann-Sofi, Etzion Ohad, Ferraz Maria Lucia G, Ferreira Paulo R A, Forns Xavier, Foster Graham R, Gaeta Giovanni B, Gamkrelidze Ivane, García-Samaniego Javier, Gheorghe Liliana S, Gholam Pierre M, Gish Robert G, Glenn Jeffrey, Hercun Julian, Hsu Yao-Chun, Hu Ching-Chih, Huang Jee-Fu, Janjua Naveed, Jia Jidong, Kåberg Martin, Kaita Kelly D E, Kamal Habiba, Kao Jia-Horng, Kondili Loreta A, Lagging Martin, Lázaro Pablo, Lazarus Jeffrey V, Lee Mei-Hsuan, Lim Young-Suk, Marotta Paul J, Navas Maria-Cristina, Naveira Marcelo C M, Orrego Mauricio, Osiowy Carla, Pan Calvin Q, Pessoa Mário G, Raimondo Giovanni, Ramji Alnoor, Razavi-Shearer Devin M, Razavi-Shearer Kathryn, Ríos-Hincapié Cielo Y, Rodríguez Manuel, Rosenberg William M C, Roulot Dominique M, Ryder Stephen D, Safadi Rifaat, Sanai Faisal M, Santantonio Teresa A, Sarrazin Christoph, Shouval Daniel, Tacke Frank, Tergast Tammo L, Villalobos-Salcedo Juan Miguel, Voeller Alexis S, Yang Hwai-I, Yu Ming-Lung, Zuckerman Eli, Polaris Observatory. Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries.. Journal of hepatology. 2023. DOI: 10.1016/j.jhep.2023.02.041.

Предметные рубрики MeSH

HumansHepatitis B virusPrevalenceHepatitis DHepatitis BHepatitis Delta VirusHepatitis B Surface AntigensHepatitis AntibodiesReflexCoinfectionRNALiver Neoplasms
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