[Effects of various modes of therapy on the fatty acid spectrum in hyperlipoproteinemia].

Gas-chromatographic investigations of the fatty acid pattern of the fractions of serum triglyceride and serum cholesterol ester revealed characteristic changes under different therapeutic measures in altogether 120 patients with primary hyperlipoproteinaemia of the types IIa, IIb and IV. Already under the treatment with basal metabolic diet, more clearly by medication with clofibrin acid, in the hyperlipoproteinaemia type IV the decrease of the palmitic acid, the palmitoleic acid, the stearic acid and oleic acid and the increase of linoleic acid, linoleneic acid, arachidonic acid and eikopentaenic acid in the triglyceride fraction developed. These fatty acids showed the same behaviour under the therapy with derivatives of nicotinic acids in the cholesterol ester fraction in the hyperlipoproteinaemia of type IIa. The combined treatment of the type IIb resulted in the same tendencies, however not so pronounced, of the spectrum in the cholesterol esters as well as of the fatty acids esterified in the triglycerides.