Pituitary · 2025
Psychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates.
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Kocaman Banu Betul, Cicek Yusuf, Sahin Serdar, Dogan Ahmet Burhan, Uysal Serhat, Muradov Ilkin, Soltanova Lala, Taze Sabriye Sibel, Usta Saglam Nazife Gamze, Durcan Emre, Turan Senol, Kadioglu Pinar
Аннотация
OBJECTIVE: This study evaluated temperament, character dimensions, anxiety, depression, and quality of life (qol) in patients with acromegaly, and examined their associations with clinical variables including disease activity, duration, treatment modality, and tumor characteristics.
METHODS: In a cross-sectional study, 77 patients with acromegaly and 99 healthy controls with no difference in age and sex compared to patients completed the Temperament and Character Inventory-Revised (TCI-R), Hospital Anxiety and Depression Scale (HADS), and Acromegaly Quality of Life Questionnaire (AcroQoL). Patients were subgrouped by remission status, treatment type, and histopathological findings. Between-group comparisons and correlation analyses were performed.
RESULTS: Compared with controls, patients with acromegaly exhibited higher impulsiveness but lower levels of emotional warmth, persistence, and self-directedness. Higher self-acceptance scores were associated with remission, while female patients exhibited significantly lower AcroQoL-Physical scores than male patients. IGF-1 levels positively correlated with novelty seeking. Qol was negatively correlated with harm avoidance, anxiety, and depression, whereas both anxiety and depression were positively associated with harm avoidance.
CONCLUSIONS: Acromegaly is associated with distinct personality patterns that may influence coping, well-being, and treatment experiences. These findings underscore the potential value of integrating psychosocial assessment and personalized support into the management of acromegaly, and highlight the need for further studies to clarify underlying neurobiological and cultural influences.
METHODS: In a cross-sectional study, 77 patients with acromegaly and 99 healthy controls with no difference in age and sex compared to patients completed the Temperament and Character Inventory-Revised (TCI-R), Hospital Anxiety and Depression Scale (HADS), and Acromegaly Quality of Life Questionnaire (AcroQoL). Patients were subgrouped by remission status, treatment type, and histopathological findings. Between-group comparisons and correlation analyses were performed.
RESULTS: Compared with controls, patients with acromegaly exhibited higher impulsiveness but lower levels of emotional warmth, persistence, and self-directedness. Higher self-acceptance scores were associated with remission, while female patients exhibited significantly lower AcroQoL-Physical scores than male patients. IGF-1 levels positively correlated with novelty seeking. Qol was negatively correlated with harm avoidance, anxiety, and depression, whereas both anxiety and depression were positively associated with harm avoidance.
CONCLUSIONS: Acromegaly is associated with distinct personality patterns that may influence coping, well-being, and treatment experiences. These findings underscore the potential value of integrating psychosocial assessment and personalized support into the management of acromegaly, and highlight the need for further studies to clarify underlying neurobiological and cultural influences.