Psychopathology · 2025
Learn to Control Your Anger: Neural Effects of Mechanism-Based Anti-Aggression Psychotherapy in Borderline Personality Disorder.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wenigmann Marc, Neukel Corinne, Spieß Karen, Bertsch Katja, Herpertz Sabine C
Аннотация
INTRODUCTION: Severe anger and overt aggression are common phenomena in borderline personality disorder (BPD) which have serious negative consequences for those affected and their environment. New developments in psychotherapy for personality disorders aim to target etiological mechanisms involved in psychopathology. Since affect dysregulation is a prominent biobehavioral mechanism underlying overt aggressive behavior in BPD, we aimed to clarify whether a psychotherapy that has been shown to decrease aggression in BPD does indeed modulate this mechanism.
METHODS: Accordingly, the neural effects of a novel mechanism-based anti-aggression psychotherapy (MAAP) were compared to those of a nonspecific supportive psychotherapy (NSSP). Twenty-seven highly overt aggressive patients with BPD and 29 healthy controls were included in this functional magnetic resonance imaging (fMRI) study.
RESULTS: The BPD patients treated with MAAP showed an increase in neural activation in clusters comprising the left anterior insula, the right dorsomedial prefrontal cortex (PFC) and the bilateral anterior caudate being related to a reduction in overt aggression. In contrast, the BPD group that had received NSSP exhibited a decrease in activity in the aforementioned clusters, each associated with a rise in overt aggressive behavior. Furthermore, MAAP showed an increase and NSSP a decrease in context-dependent functional connectivity between the caudate seed cluster mentioned above and the left dorsolateral PFC. Likewise, this interaction effect was negatively related to the change in overt aggression with an OAS-M reduction for the MAAP and a rise for the NSSP group.
CONCLUSION: The data may suggest that the aggression-reducing effect of MAAP is mediated through increasing cognitive control over dysregulated feelings of anger.
METHODS: Accordingly, the neural effects of a novel mechanism-based anti-aggression psychotherapy (MAAP) were compared to those of a nonspecific supportive psychotherapy (NSSP). Twenty-seven highly overt aggressive patients with BPD and 29 healthy controls were included in this functional magnetic resonance imaging (fMRI) study.
RESULTS: The BPD patients treated with MAAP showed an increase in neural activation in clusters comprising the left anterior insula, the right dorsomedial prefrontal cortex (PFC) and the bilateral anterior caudate being related to a reduction in overt aggression. In contrast, the BPD group that had received NSSP exhibited a decrease in activity in the aforementioned clusters, each associated with a rise in overt aggressive behavior. Furthermore, MAAP showed an increase and NSSP a decrease in context-dependent functional connectivity between the caudate seed cluster mentioned above and the left dorsolateral PFC. Likewise, this interaction effect was negatively related to the change in overt aggression with an OAS-M reduction for the MAAP and a rise for the NSSP group.
CONCLUSION: The data may suggest that the aggression-reducing effect of MAAP is mediated through increasing cognitive control over dysregulated feelings of anger.