Clinics (Sao Paulo, Brazil) · 2025
The hidden connection: systemic immune-inflammation index and its role in asthma.
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Peng Cheng, Gao Dong, Zhou Zanchen, Wang Tiancheng
Аннотация
BACKGROUND: This study explores potential associations between asthma and the Systemic Immune-Inflammation Index (SII).
METHODS: The study primarily focuses on adults with complete data on SII and asthma from the National Health and Nutrition Examination Survey database (2015-2020). SII is calculated using the formula: platelet count × neutrophil count / lymphocyte count. The connection between SII and asthma was assessed through baseline feature analysis, weighted multivariate regression, subgroup analysis, and smooth curve fitting.
RESULTS: A total of 13,334 participants were included, with 2045 individuals (15.34 %) having asthma. Subgroup analysis and interaction tests revealed no significant impact of gender, age, body mass index, vitamin C, magnesium, coronary heart disease, or diabetes on the observed association (p for interaction > 0.05).
CONCLUSION: Higher SII levels are associated with an increased incidence of asthma. Further prospective studies are needed to confirm these findings.
METHODS: The study primarily focuses on adults with complete data on SII and asthma from the National Health and Nutrition Examination Survey database (2015-2020). SII is calculated using the formula: platelet count × neutrophil count / lymphocyte count. The connection between SII and asthma was assessed through baseline feature analysis, weighted multivariate regression, subgroup analysis, and smooth curve fitting.
RESULTS: A total of 13,334 participants were included, with 2045 individuals (15.34 %) having asthma. Subgroup analysis and interaction tests revealed no significant impact of gender, age, body mass index, vitamin C, magnesium, coronary heart disease, or diabetes on the observed association (p for interaction > 0.05).
CONCLUSION: Higher SII levels are associated with an increased incidence of asthma. Further prospective studies are needed to confirm these findings.