Medical physics · 2025
Grating-based x-ray dark-field mammography: Assessing complementary imaging information in simple cystic lesions and typical fibroadenoma.
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Hellerhoff Karin, Gottwald Wolfgang, Taphorn Kirsten, Berthe Daniel, Braun Michael, Wagner Kai, Resch Sandra, John Dominik, Heck Lisa, Birnbacher Lorenz, Herzen Julia, Grandl Susanne
Аннотация
BACKGROUND: A significant proportion of false positive recalls of mammography-screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth-shaped dense masses and require the recalling of women for a breast ultrasound to obtain complementary imaging information. They can be identified safely by ultrasound with no need for further assessment or treatment.
PURPOSE: Grating-based x-ray dark-field breast imaging allows contrast formation based on both attenuation and small-angle x-ray scattering and provides complementary imaging information in one single acquisition.
METHODS: Experiments with ex-vivo mastectomy samples were performed with a three-grating Talbot-Lau interferometer using a laboratory-based polychromatic x-ray source. Attenuation and dark-field images were correlated to clinical mammography and complementary diagnostic imaging techniques.
RESULTS: Benign breast lesions with homogeneous internal structures such as fibroadenomas and simple fluid-filled cysts, typically presenting as dense breast lesions in standard mammography, showed a signal drop in the dark-field image. Complicated cysts provided a higher dark-field signal.
CONCLUSIONS: The results presented show that grating-based x-ray dark-field mammography could provide complementary imaging information in one single acquisition, eliminating the need for a second examination to identify harmless cysts and simple fibroadenomas.
PURPOSE: Grating-based x-ray dark-field breast imaging allows contrast formation based on both attenuation and small-angle x-ray scattering and provides complementary imaging information in one single acquisition.
METHODS: Experiments with ex-vivo mastectomy samples were performed with a three-grating Talbot-Lau interferometer using a laboratory-based polychromatic x-ray source. Attenuation and dark-field images were correlated to clinical mammography and complementary diagnostic imaging techniques.
RESULTS: Benign breast lesions with homogeneous internal structures such as fibroadenomas and simple fluid-filled cysts, typically presenting as dense breast lesions in standard mammography, showed a signal drop in the dark-field image. Complicated cysts provided a higher dark-field signal.
CONCLUSIONS: The results presented show that grating-based x-ray dark-field mammography could provide complementary imaging information in one single acquisition, eliminating the need for a second examination to identify harmless cysts and simple fibroadenomas.