European journal of obstetrics, gynecology, and reproductive biology · 1994
Amino acids, glucose and lactate concentrations in umbilical cord blood in relation to umbilical artery flow patterns.
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Karsdorp V H, van Vugt J M, Jakobs C, Dekker G A, van Geijn H P
Аннотация
OBJECTIVE: To study possible relationships between abnormal placental perfusion, hypoxemia and impaired fetal nutrient supply.
STUDY DESIGN: Umbilical artery flow velocity waveforms were assessed in high risk pregnancies and compared with controls. Three groups were studied. In group I (n = 13) the pulsatility index (PI) was within normal limits, in group II (n = 9) PI was > 2 S.D. in the presence of positive end diastolic velocities and in group III (n = 13) end diastolic velocities were absent. pH and PO2 levels and concentrations of amino acids, glucose and lactate were measured in umbilical blood obtained at cesarean section (n = 35).
RESULTS: An inverse correlation was found between concentrations of essential amino acids concentrations and the pulsatility index in the umbilical artery (P = 0.03). No correlation with hypoxemia was found (P = 0.32). The glycine/valine ratio was significantly increased in the groups with abnormal Doppler velocity indices (P = 0.02). Glucose concentrations were significantly reduced in the case of absent end diastolic velocities (P = 0.001). No significant differences were found between the three groups concerning lactate concentrations and acid-base balance parameters.
CONCLUSIONS: These findings, especially the increased glycine/valine ratio, which is characteristic for kwashiorkor, indicate that abnormal placental perfusion is associated with impaired fetal nutrient supply, in the presence of a normal fetal oxygenation.
STUDY DESIGN: Umbilical artery flow velocity waveforms were assessed in high risk pregnancies and compared with controls. Three groups were studied. In group I (n = 13) the pulsatility index (PI) was within normal limits, in group II (n = 9) PI was > 2 S.D. in the presence of positive end diastolic velocities and in group III (n = 13) end diastolic velocities were absent. pH and PO2 levels and concentrations of amino acids, glucose and lactate were measured in umbilical blood obtained at cesarean section (n = 35).
RESULTS: An inverse correlation was found between concentrations of essential amino acids concentrations and the pulsatility index in the umbilical artery (P = 0.03). No correlation with hypoxemia was found (P = 0.32). The glycine/valine ratio was significantly increased in the groups with abnormal Doppler velocity indices (P = 0.02). Glucose concentrations were significantly reduced in the case of absent end diastolic velocities (P = 0.001). No significant differences were found between the three groups concerning lactate concentrations and acid-base balance parameters.
CONCLUSIONS: These findings, especially the increased glycine/valine ratio, which is characteristic for kwashiorkor, indicate that abnormal placental perfusion is associated with impaired fetal nutrient supply, in the presence of a normal fetal oxygenation.