Bipolar symptoms, somatic burden and functioning in older-age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project.
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Sajatovic Martha, Rej Soham, Almeida Osvaldo P, Altinbas Kursat, Balanzá-Martínez Vicent, Barbosa Izabela G, Beunders Alexandra J M, Blumberg Hilary P, Briggs Farren B S, Dols Annemiek, Forester Brent P, Forlenza Orestes V, Gildengers Ariel G, Jimenez Esther, Klaus Federica, Lafer Beny, Mulsant Benoit, Mwangi Benson, Nunes Paula Villela, Olagunju Andrew T, Oluwaniyi Stephen, Orhan Melis, Patrick Regan E, Radua Joaquim, Rajji Tarek, Sarna Kaylee, Schouws Sigfried, Simhandl Christian, Sekhon Harmehr, Soares Jair C, Sutherland Ashley N, Teixeira Antonio L, Tsai Shangying, Vidal-Rubio Sonia, Vieta Eduard, Yala Joy, Eyler Lisa T
Аннотация
DESIGN/METHODS: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the combined W1 + W2 sample (n = 2601).
RESULTS: Compared to W1, the W2 sample was younger (p < 0.001), less educated (p < 0.001), more symptomatic (p < 0.001), lower functioning (p < 0.001) and had fewer somatic conditions (p < 0.001). In the full W2, older individuals had reduced manic symptom severity, but age was not associated with depression severity. Age was not associated with functioning in W2. More severe BD symptoms (mania p ≤ 0.001, depression p ≤ 0.001) were associated with worse functioning. Older age was significantly associated with higher somatic burden in the W2 and the W1 + W2 samples, but this burden was not associated with poorer functioning.
CONCLUSIONS: In a large, independent sample, older age was associated with less severe mania and more somatic burden (consistent with previous findings), but there was no association of depression with age (different from previous findings). Similar to previous findings, worse BD symptom severity was associated with worse functioning, emphasizing the need for symptom relief in OABD to promote better functioning.