Medicine · 2019
Mixed large and small cell neuroendocrine carcinoma of the endometrium with serous carcinoma: A case report and literature review.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hu Ruijiao, Jiang Jiyong, Song Guangyao, Zhu Chenggong, Chen Liyan, Wang Chenhui, Wang Xiuying
Аннотация
RATIONALE: Endometrial neuroendocrine carcinoma is a rare histological subtype of endometrial cancer, divided into low-grade neuroendocrine carcinoma (carcinoid) and high-grade neuroendocrine carcinoma (small cell and large cell neuroendocrine carcinoma). It is characterized by high invasiveness and poor prognosis. L/SCNEC is an extremely rare pathological type of endometrial carcinoma, and the number of reports on this condition is few globally.
PATIENT CONCERNS: A 54-year-old Chinese female presented with vaginal bleeding.
DIAGNOSES: Outpatient hysteroscopy and endometrial biopsy were performed, and the pathological examination revealed that cervix was invaded by endometrial malignancy. The patient underwent a laparoscopic radical hysterectomy was diagnosed with the mixed large and small cell neuroendocrine carcinoma (L/SCNEC) of the endometrium combined with serous carcinoma III C2 (FIGO2009).
INTERVENTIONS: Chemotherapy-radiotherapy-chemotherapy "sandwich" treatment was performed as postoperative therapy.
OUTCOMES: After three chemotherapy circles, the patient showed no evidence of further disease progression.
LESSONS: L/SCNEC is a rare and invasive disease. Once diagnosed, comprehensive treatments including surgery, radiotherapy, and chemotherapy can prolong the survival of patients and improve the prognosis.
PATIENT CONCERNS: A 54-year-old Chinese female presented with vaginal bleeding.
DIAGNOSES: Outpatient hysteroscopy and endometrial biopsy were performed, and the pathological examination revealed that cervix was invaded by endometrial malignancy. The patient underwent a laparoscopic radical hysterectomy was diagnosed with the mixed large and small cell neuroendocrine carcinoma (L/SCNEC) of the endometrium combined with serous carcinoma III C2 (FIGO2009).
INTERVENTIONS: Chemotherapy-radiotherapy-chemotherapy "sandwich" treatment was performed as postoperative therapy.
OUTCOMES: After three chemotherapy circles, the patient showed no evidence of further disease progression.
LESSONS: L/SCNEC is a rare and invasive disease. Once diagnosed, comprehensive treatments including surgery, radiotherapy, and chemotherapy can prolong the survival of patients and improve the prognosis.
Предметные рубрики MeSH
Antineoplastic Combined Chemotherapy ProtocolsBiopsyCarcinoma, NeuroendocrineCarcinoma, Small CellChemotherapy, AdjuvantCombined Modality TherapyCystadenocarcinoma, SerousEndometrial NeoplasmsEndometriumFemaleHumansHysterectomyMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingTreatment OutcomeUterine Hemorrhage