Nature · 2024
Pathogenicity and transmissibility of bovine H5N1 influenza virus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Eisfeld Amie J, Biswas Asim, Guan Lizheng, Gu Chunyang, Maemura Tadashi, Trifkovic Sanja, Wang Tong, Babujee Lavanya, Dahn Randall, Halfmann Peter J, Barnhardt Tera, Neumann Gabriele, Suzuki Yasuo, Thompson Alexis, Swinford Amy K, Dimitrov Kiril M, Poulsen Keith, Kawaoka Yoshihiro
Аннотация
Highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in mammals. In the spring of 2024, an unprecedented outbreak of HPAI H5N1 in bovine herds occurred in the USA, with virus spread within and between herds, infections in poultry and cats, and spillover into humans, collectively indicating an increased public health risk1-4. Here we characterize an HPAI H5N1 virus isolated from infected cow milk in mice and ferrets. Like other HPAI H5N1 viruses, the bovine H5N1 virus spread systemically, including to the mammary glands of both species, however, this tropism was also observed for an older HPAI H5N1 virus isolate. Bovine HPAI H5N1 virus bound to sialic acids expressed in human upper airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate infection and transmission in mammals.