BMC veterinary research · 2024
Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis.
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de Carvalho Araujo Andreina, Cho Andrew Yong, Silva Laura Morais Nascimento, Corrêa Thais Camilo, de Souza Gabriela Cristini, Albuquerque Adriana Silva, Macagnan Eduardo, Kolesnikvoas Cristiane K M, Meurer Rafael, Vieira Jenyffer Vierheller, Lemos Giulia Gaglianone, Barreto André Silva, Dick Jeferson Luis, Groch Karina Rejane, de Castilho Pedro Volkmer, Amgarten Deyvid, Malta Fernanda, Miller Michael, Dorlass Erick G, Palameta Soledad, Lee Sun-Hak, Arns Clarice Weis, Durigon Edison L, Pinho João Renato R, Lee Dong-Hun, Ferreira Helena Lage
Аннотация
Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts.