Медицинская библиотека · BMC veterinary research · 2024

Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis.

de Carvalho Araujo Andreina, Cho Andrew Yong, Silva Laura Morais Nascimento, Corrêa Thais Camilo, de Souza Gabriela Cristini, Albuquerque Adriana Silva, Macagnan Eduardo, Kolesnikvoas Cristiane K M, Meurer Rafael, Vieira Jenyffer Vierheller, Lemos Giulia Gaglianone, Barreto André Silva, Dick Jeferson Luis, Groch Karina Rejane, de Castilho Pedro Volkmer, Amgarten Deyvid, Malta Fernanda, Miller Michael, Dorlass Erick G, Palameta Soledad, Lee Sun-Hak, Arns Clarice Weis, Durigon Edison L, Pinho João Renato R, Lee Dong-Hun, Ferreira Helena Lage

СтатьяПеревод пока не подготовлен

Аннотация

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts.

Для цитирования: de Carvalho Araujo Andreina, Cho Andrew Yong, Silva Laura Morais Nascimento, Corrêa Thais Camilo, de Souza Gabriela Cristini, Albuquerque Adriana Silva, Macagnan Eduardo, Kolesnikvoas Cristiane K M, Meurer Rafael, Vieira Jenyffer Vierheller, Lemos Giulia Gaglianone, Barreto André Silva, Dick Jeferson Luis, Groch Karina Rejane, de Castilho Pedro Volkmer, Amgarten Deyvid, Malta Fernanda, Miller Michael, Dorlass Erick G, Palameta Soledad, Lee Sun-Hak, Arns Clarice Weis, Durigon Edison L, Pinho João Renato R, Lee Dong-Hun, Ferreira Helena Lage. Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis.. BMC veterinary research. 2024. DOI: 10.1186/s12917-024-04137-1.

Предметные рубрики MeSH

Animals Phylogeny Sea Lions Brazil Whole Genome Sequencing Influenza A Virus, H5N1 Subtype Orthomyxoviridae Infections Genome, Viral Genotype Genetic Variation

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.

Аннотация

Предметные рубрики MeSH

Ошибки и ограничения