Compression sleeves for prevention and treatment of breast cancer-related lymphedema: a systematic review and meta-analysis.

BACKGROUND

Compression sleeves are widely used for breast cancer-related lymphedema, but evidence on their effectiveness of prevention and treatment in volume reduction is limited.

OBJECTIVE

To compare the effects of compression sleeves and conventional care on breast cancer-related lymphedema, providing evidence-based support for clinical application.

METHODS

A systematic search of 9 databases was conducted up to June 9, 2025. Meta-analysis was performed using RevMan 5.4, and evidence quality was assessed with GRADE profiler 3.6.

RESULTS

1532 patients were included. Compression sleeves significantly reduced lymphedema incidence post-surgery (P =0 .02) and edema volume/circumference (P <0 .001), and improved shoulder flexion (P =0.02). No significant effects were seen on shoulder abduction (P =0 .18), subjective symptoms (P =0.62), or quality of life (P = 0.32). Evidence quality was moderate for incidence and volume/circumference reduction, and low for other outcomes.

CONCLUSION

This meta-analysis shows that compression sleeves reduce lymphedema incidence and volume/circumference, and improve shoulder flexion. They should be considered in lymphedema management, though further research is needed for other outcomes.