Медицинская библиотека · Biomedical and environmental sciences : BES · 2007

Evaluation of two anti-hepatitis E virus IgM kits.

Ge Sheng-Xiang, Zheng Ying-Jie, Guo Qing-Shun, Zhang Jun, Jiang Qing-Wu, Ng Mun-Hon, Xia Ning-Shao

Оценочное исследованиеСтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To evaluate two commercial anti-hepatitis E virus (HEV) IgM kits used for differential diagnosis of acute enteric viral hepatitis.

METHODS

The kit for IgM capture assay, was produced with a recombinant HEV structural protein protecting primates against experimental infection by different HEV genotypes, while the other kit for indirect ELISA was produced with recombinant structural proteins from different HEV genotypes. The serum specimens were taken from 241 cases with a confirmed or presumptive diagnosis of hepatitis A and 74 cases with a confirmed or presumptive diagnosis of hepatitis E.

RESULTS

The sensitivity and specificity of the IgM capture assay kit were 97% and 100%, respectively, and the corresponding values for the other kit were 70% and 78%, respectively.

CONCLUSION

The IgM capture assay kit has higher sensitivity and specificity in diagnosing acute enteric viral hepatitis E.

Для цитирования: Ge Sheng-Xiang, Zheng Ying-Jie, Guo Qing-Shun, Zhang Jun, Jiang Qing-Wu, Ng Mun-Hon, Xia Ning-Shao. Evaluation of two anti-hepatitis E virus IgM kits.. Biomedical and environmental sciences : BES. 2007.

Предметные рубрики MeSH

Diagnosis, Differential Hepatitis E Humans Immunoglobulin M Reagent Kits, Diagnostic Sensitivity and Specificity

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