Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2026
Prevalence and clinical correlates of pre-operative glucose homeostasis in patients with acromegaly.
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Chiang Po-Wei, Chen Harn-Shen
Аннотация
CONTEXT: Comprehensive assessments of the prevalence of prediabetes and glucose intolerance are scarce for acromegaly.
OBJECTIVE: To estimate the prevalence of pre-operative glucose homeostasis in patients with acromegaly, including diabetes mellitus (DM), impaired fasting glucose, impaired glucose tolerance, and prediabetes.
DESIGN: The study encompassed patients diagnosed with acromegaly at Taipei Veterans General Hospital from 1977 to 2020. Known DM was defined as the use of anti-diabetic medication. Newly diagnosed DM was defined as any of the following conditions: a fasting PG concentration ≥ 126 mg/dL, 2-h glucose concentration ≥ 200 mg/dL during the OGTT, or HbA1c level ≥ 6.5%. Normal glucose tolerance (NGT) was defined as a fasting PG concentration < 100 mg/dL, 2-h glucose concentration < 140 mg/dL during the OGTT, HbA1c level < 5.7%, and not using anti-diabetic medication. Patients who did not meet the criteria for either DM or NGT were classified as having prediabetes.
RESULTS: Of 177 patients, 83 (46.9%) had diabetes-39 pre-existing and 44 newly diagnosed. Normal glucose tolerance (NGT) occurred in 32 patients (18.1%), while 62 (35.0%) had prediabetes. Among those with prediabetes, impaired fasting glucose was noted in 59 (39.3% of those with fasting data), impaired glucose tolerance in 47 (34.3% of those with OGTT data), and HbA1c levels of 5.7-6.4% in 19 (28.0% of those with HbA1c data).
CONCLUSION: Our findings on diagnosis and prevalence of various blood-glucose statuses in patients with acromegaly at the pre-operative stage may suggest novel mechanisms worthy of further investigation.
OBJECTIVE: To estimate the prevalence of pre-operative glucose homeostasis in patients with acromegaly, including diabetes mellitus (DM), impaired fasting glucose, impaired glucose tolerance, and prediabetes.
DESIGN: The study encompassed patients diagnosed with acromegaly at Taipei Veterans General Hospital from 1977 to 2020. Known DM was defined as the use of anti-diabetic medication. Newly diagnosed DM was defined as any of the following conditions: a fasting PG concentration ≥ 126 mg/dL, 2-h glucose concentration ≥ 200 mg/dL during the OGTT, or HbA1c level ≥ 6.5%. Normal glucose tolerance (NGT) was defined as a fasting PG concentration < 100 mg/dL, 2-h glucose concentration < 140 mg/dL during the OGTT, HbA1c level < 5.7%, and not using anti-diabetic medication. Patients who did not meet the criteria for either DM or NGT were classified as having prediabetes.
RESULTS: Of 177 patients, 83 (46.9%) had diabetes-39 pre-existing and 44 newly diagnosed. Normal glucose tolerance (NGT) occurred in 32 patients (18.1%), while 62 (35.0%) had prediabetes. Among those with prediabetes, impaired fasting glucose was noted in 59 (39.3% of those with fasting data), impaired glucose tolerance in 47 (34.3% of those with OGTT data), and HbA1c levels of 5.7-6.4% in 19 (28.0% of those with HbA1c data).
CONCLUSION: Our findings on diagnosis and prevalence of various blood-glucose statuses in patients with acromegaly at the pre-operative stage may suggest novel mechanisms worthy of further investigation.