Neuropsychobiology · 2008
Decreased density of the platelet serotonin transporter in pathological gamblers.
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Marazziti Donatella, Golia Francesca, Picchetti Michela, Pioli Ellena, Mannari Patrizia, Lenzi Francesco, Conversano Ciro, Carmassi Claudia, Catena Dell'Osso Mario, Consoli Giorgio, Baroni Stefano, Giannaccini Gino, Zanda Giuseppe, Dell'Osso Liliana
Аннотация
BACKGROUND/AIMS: The aim of this study was to investigate the serotonin transporter (SERT), by means of the 3H-paroxetine ([3H]-Par) binding to platelet membranes, in patients affected by pathological gambling (PG), as compared with a similar group of healthy control subjects.
METHODS: Seventeen PG patients were selected amongst those who were drug-free and at the first psychiatric interview in a Department of Addiction. The diagnosis was assessed according to DSM-IV criteria and PG severity was measured by means of the South Oaks Gambling Screen. The platelet [3H]-Par binding was carried out according to a standardized method. The binding parameters, the maximum binding capacity (B(max)) and the dissociation constant (K(d)), were obtained by means of the Scatchard analysis.
RESULTS: The B(max) values of PG patients were significantly lower than that of healthy subjects, while the K(d) values were not different in the two groups. No significant effect of age, sex or psychiatric comorbidity on B(max) or K(d) was observed; there were also no correlations between clinical and biological variables.
CONCLUSIONS: PG patients showed a dysfunction at the level of the platelet SERT that would suggest the involvement of the 5-HT system in this condition.
METHODS: Seventeen PG patients were selected amongst those who were drug-free and at the first psychiatric interview in a Department of Addiction. The diagnosis was assessed according to DSM-IV criteria and PG severity was measured by means of the South Oaks Gambling Screen. The platelet [3H]-Par binding was carried out according to a standardized method. The binding parameters, the maximum binding capacity (B(max)) and the dissociation constant (K(d)), were obtained by means of the Scatchard analysis.
RESULTS: The B(max) values of PG patients were significantly lower than that of healthy subjects, while the K(d) values were not different in the two groups. No significant effect of age, sex or psychiatric comorbidity on B(max) or K(d) was observed; there were also no correlations between clinical and biological variables.
CONCLUSIONS: PG patients showed a dysfunction at the level of the platelet SERT that would suggest the involvement of the 5-HT system in this condition.
Предметные рубрики MeSH
AdultBinding SitesBlood PlateletsCell CountDemographyDiagnostic and Statistical Manual of Mental DisordersDisruptive, Impulse Control, and Conduct DisordersFemaleGamblingHumansMaleParoxetinePlatelet Membrane GlycoproteinsSerotonin Plasma Membrane Transport ProteinsSelective Serotonin Reuptake Inhibitors