China CDC weekly · 2024
Emerging Sialylated Class R Lipooligosaccharides in Campylobacter jejuni from Seagulls Has the Potential to Trigger Guillain-Barré Syndrome - Yunnan Province, China, 2018-2023.
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Chen Xiaoli, Gu Yixin, Wang Hairui, Zhou Guilan, Zhang Xin, Liu Chang, Shao Zhujun, Zhang Jianzhong, Zhang Maojun
Аннотация
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Lipooligosaccharides from Campylobacter jejuni (C. jejuni) have a mimicry antigen structure with gangliosides, which explains the mechanism by which C. jejuni caused Guillain-Barré syndrome (GBS).
WHAT IS ADDED BY THIS REPORT?: All 12 C. jejuni strains with class R LOSs and specific serotypes were isolated from seagulls in south China. These emerging C. jejuni strains had ganglioside-mimicry antigen structures and possessed a high potential for triggering GBS.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Sialylated lipooligosaccharides (LOS) class R with GBS-associated serotypes isolated from seagulls highlight the risk of induced GBS around coastal or lakeside areas.
WHAT IS ADDED BY THIS REPORT?: All 12 C. jejuni strains with class R LOSs and specific serotypes were isolated from seagulls in south China. These emerging C. jejuni strains had ganglioside-mimicry antigen structures and possessed a high potential for triggering GBS.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: Sialylated lipooligosaccharides (LOS) class R with GBS-associated serotypes isolated from seagulls highlight the risk of induced GBS around coastal or lakeside areas.