Journal of the National Cancer Institute · 2016
Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Anglesio Michael S, Wang Yi Kan, Maassen Madlen, Horlings Hugo M, Bashashati Ali, Senz Janine, Mackenzie Robertson, Grewal Diljot S, Li-Chang Hector, Karnezis Anthony N, Sheffield Brandon S, McConechy Melissa K, Kommoss Friedrich, Taran Florin A, Staebler Annette, Shah Sohrab P, Wallwiener Diethelm, Brucker Sara, Gilks C Blake, Kommoss Stefan, Huntsman David G
Аннотация
Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave as independent primary tumors rather than a single advanced-stage carcinoma. We used 18 SEOs to investigate the ancestral relationship between the endometrial and ovarian components. Based on both targeted and exome sequencing, 17 of 18 patient cases of simultaneous cancer of the endometrium and ovary from our series showed evidence of a clonal relationship, ie, primary tumor and metastasis. Eleven patient cases fulfilled clinicopathological criteria that would lead to classification as independent endometrial and ovarian primary carcinomas, including being of FIGO stage T1a/1A, with organ-restricted growth and without surface involvement; 10 of 11 of these cases showed evidence of clonality. Our observations suggest that the disseminating cells amongst SEOs are restricted to physically accessible and microenvironment-compatible sites yet remain indolent, without the capacity for further dissemination.