European journal of medical research · 2026
Differences in the profile of mild cognitive impairment among inpatients with T2DM: a comparison of the MMSE and MoCA.
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Liu Yamin, Maimaitituerxun Rehanguli, Chen Wenhang, Chen Letao, Xiao Fang, Wu Xin Yin, Yang Jianzhou, Tang Yuxin, Dai Wenjie
Аннотация
OBJECTIVE: This study aimed to identify the differences in the profile of mild cognitive impairment (MCI) among inpatients with type II diabetes mellitus (T2DM) by using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
METHOD: This hospital-based cross-sectional study included consecutive T2DM in patients who were admitted to the Endocrinology Department of Xiangya Hospital Affiliated with Central South University from July 1, 2022, to December 31, 2022. Demographic characteristics, lifestyle information, medical history, and clinical features were collected using a standard questionnaire via face-to-face interviews by well-trained investigators. MCI was defined as the early stage of cognitive decline, and measured by MMSE and MoCA with education-specific cutoffs. Multivariate logistic regression analyses were used to determine factors associated with MCI detected by MMSE or MoCA.
RESULTS: A total of 474 participants were included. The prevalence of MCI detected by MMSE and MoCA was 18.4% and 51.9%, respectively. The MMSE had fair agreement with the MoCA for detecting MCI (kappa value = 0.287), and the MMSE score correlated significantly with the MoCA score (rs = 0.82, P < 0.001). Age and diabetic nephropathy were associated with MCI by both MMSE and MoCA. Regular physical activity was only associated with MCI by the MMSE, educational level, household income, and stroke were only associated with MCI by the MoCA.
CONCLUSIONS: The MoCA was more sensitive than the MMSE in screening for MCI among inpatients with T2DM, as it detected more MCI patients. However, cautious should apply since this might come at the cost of specificity, given the lack of a gold-standard diagnosis in this study. In addition to age, diabetic nephropathy, regular physical activity, educational level, household income, and stroke status were considered modifiable factors for MCI among inpatients with T2DM, which provides important evidence for establishing intervention measures.
METHOD: This hospital-based cross-sectional study included consecutive T2DM in patients who were admitted to the Endocrinology Department of Xiangya Hospital Affiliated with Central South University from July 1, 2022, to December 31, 2022. Demographic characteristics, lifestyle information, medical history, and clinical features were collected using a standard questionnaire via face-to-face interviews by well-trained investigators. MCI was defined as the early stage of cognitive decline, and measured by MMSE and MoCA with education-specific cutoffs. Multivariate logistic regression analyses were used to determine factors associated with MCI detected by MMSE or MoCA.
RESULTS: A total of 474 participants were included. The prevalence of MCI detected by MMSE and MoCA was 18.4% and 51.9%, respectively. The MMSE had fair agreement with the MoCA for detecting MCI (kappa value = 0.287), and the MMSE score correlated significantly with the MoCA score (rs = 0.82, P < 0.001). Age and diabetic nephropathy were associated with MCI by both MMSE and MoCA. Regular physical activity was only associated with MCI by the MMSE, educational level, household income, and stroke were only associated with MCI by the MoCA.
CONCLUSIONS: The MoCA was more sensitive than the MMSE in screening for MCI among inpatients with T2DM, as it detected more MCI patients. However, cautious should apply since this might come at the cost of specificity, given the lack of a gold-standard diagnosis in this study. In addition to age, diabetic nephropathy, regular physical activity, educational level, household income, and stroke status were considered modifiable factors for MCI among inpatients with T2DM, which provides important evidence for establishing intervention measures.