Journal of atherosclerosis and thrombosis · 2026
An Elevated Serum Apolipoprotein C-III Concentration is Associated with the Risk of Coronary Heart Disease in a Japanese General Population. The Hidaka Cohort Study.
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Fujioka Yoshio, Tanaka Shin-Ichiro, Tsujino Takeshi, Ishida Tatsuro, Hirata Ken-Ichi
Аннотация
AIM: Apolipoprotein CIII (ApoC-III) is a lipid-associated protein crucial for the lipid metabolism. Recent studies have shown that ApoC-III also plays a role in vascular dysfunction and the development of coronary heart disease (CHD). This study examined the hypothesis that the serum ApoC-III concentration is associated with the future risk of CHD in a general Japanese population.
METHODS: We prospectively studied 1,676 individuals (1,005 women, 671 men; mean age 57.1 years) in a rural community in Japan. In the 1993 baseline survey, anthropometric examinations, current smoking status, blood pressure, and serum concentrations of lipids and apolipoproteins were assessed. During the follow-up period of 10.9 years (interquartile range 10.8 - 11.1), 48 participants developed CHD, including 18 fatal and non-fatal myocardial infarction patients and 30 sudden death cases.
RESULTS: In the age- and sex-adjusted analysis, we did not find any association between the baseline serum ApoC-III concentration and the risk of CHD and sudden death (HR 2.11, CI 0.88 - 5.03, P = 0.094). However, in a multivariable analysis adjusted for age, sex, the presence of hypertension, presence of diabetes mellitus, current smoking status, total cholesterol, high-density lipoprotein cholesterol, and triglycerides, serum ApoC-III concentration was significantly associated with the risk of CHD and sudden death (HR 3.59, CI 1.05 - 12.3, P = 0.041).
CONCLUSION: Serum ApoC-III concentration was independently associated with the risk of CHD and sudden death in a general Japanese population.
METHODS: We prospectively studied 1,676 individuals (1,005 women, 671 men; mean age 57.1 years) in a rural community in Japan. In the 1993 baseline survey, anthropometric examinations, current smoking status, blood pressure, and serum concentrations of lipids and apolipoproteins were assessed. During the follow-up period of 10.9 years (interquartile range 10.8 - 11.1), 48 participants developed CHD, including 18 fatal and non-fatal myocardial infarction patients and 30 sudden death cases.
RESULTS: In the age- and sex-adjusted analysis, we did not find any association between the baseline serum ApoC-III concentration and the risk of CHD and sudden death (HR 2.11, CI 0.88 - 5.03, P = 0.094). However, in a multivariable analysis adjusted for age, sex, the presence of hypertension, presence of diabetes mellitus, current smoking status, total cholesterol, high-density lipoprotein cholesterol, and triglycerides, serum ApoC-III concentration was significantly associated with the risk of CHD and sudden death (HR 3.59, CI 1.05 - 12.3, P = 0.041).
CONCLUSION: Serum ApoC-III concentration was independently associated with the risk of CHD and sudden death in a general Japanese population.